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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2B
All Species:
40.61
Human Site:
Y267
Identified Species:
59.56
UniProt:
P31323
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31323
NP_002727.2
418
46302
Y267
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
Y326
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
Y310
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Dog
Lupus familis
XP_849179
417
46163
Y266
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P31324
416
46149
Y265
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Rat
Rattus norvegicus
P12369
416
46104
Y265
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
L185
S
L
P
F
L
K
S
L
D
V
S
E
R
L
K
Chicken
Gallus gallus
Q5ZM91
382
43332
R242
I
L
M
G
S
T
L
R
K
R
K
M
Y
E
E
Frog
Xenopus laevis
NP_001084637
402
45172
Y251
N
A
K
K
R
R
L
Y
E
N
F
I
E
S
L
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
Y249
N
A
K
K
R
R
M
Y
E
C
F
I
E
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
Y233
A
F
R
K
R
K
M
Y
E
E
L
L
N
S
V
Honey Bee
Apis mellifera
XP_392905
383
43849
Y239
A
Y
K
K
R
K
M
Y
E
D
L
I
N
K
V
Nematode Worm
Caenorhab. elegans
P30625
366
41449
R228
M
G
S
V
T
K
K
R
K
M
Y
D
E
F
L
Sea Urchin
Strong. purpuratus
Q26619
369
41770
Y230
A
A
K
K
R
R
I
Y
E
E
L
L
E
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
A272
T
S
D
C
L
L
W
A
L
D
R
L
T
F
R
Red Bread Mold
Neurospora crassa
Q01386
385
42138
E243
T
F
R
R
I
L
M
E
S
T
F
S
R
R
R
Conservation
Percent
Protein Identity:
100
86.5
90
96.6
N.A.
97.1
96.8
N.A.
70.3
34.6
78.4
68.1
N.A.
44
47.6
31.8
50.9
Protein Similarity:
100
87.2
90.2
98
N.A.
98
98.5
N.A.
74.1
52.3
85.4
80.6
N.A.
64.1
63.8
50.9
66.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
0
80
80
N.A.
46.6
53.3
20
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
20
100
93.3
N.A.
66.6
60
33.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
36.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.9
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
57
0
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
7
13
0
7
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
7
69
13
0
7
63
7
7
% E
% Phe:
0
13
0
7
0
0
0
0
0
0
57
0
0
13
0
% F
% Gly:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
7
0
7
0
0
0
0
57
0
0
7
% I
% Lys:
0
0
63
69
0
63
7
0
13
0
7
0
0
13
7
% K
% Leu:
0
13
0
0
13
13
13
7
7
0
19
19
0
7
50
% L
% Met:
7
0
7
0
0
0
63
0
0
7
0
7
0
0
0
% M
% Asn:
50
0
0
0
0
0
0
0
0
7
0
0
13
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
13
7
69
19
0
13
0
7
7
0
13
7
13
% R
% Ser:
7
7
7
0
7
0
7
0
7
38
7
7
0
57
0
% S
% Thr:
13
0
0
0
7
7
0
0
0
7
0
0
7
0
0
% T
% Val:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
19
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
69
0
0
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _